منابع مشابه
Unraveling ambiguous NAT2 genotyping data.
BACKGROUND Arylamine N-acetyltransferase 2 (CoASAc; NAT2, EC 2.3.1.5) is a drug-metabolizing enzyme that displays common polymorphisms leading to impaired drug metabolism and adverse drug effects. Determination of the N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2) genotype in clinical practice is hampered by the occurrence of ambiguous haplotype combinations that may lead to patie...
متن کاملQuality of NAT2 genotyping with restriction fragment length polymorphism using DNA isolated from frozen urine.
In large studies and under field conditions common to epidemiological research, factors outside of and inside the laboratory can introduce misclassification of genetic susceptibility markers. Few reports have been made on the accuracy of genotyping individuals using DNA extracted from frozen urine that was stored for approximately 20 years. This study was performed to determine the reproducibil...
متن کاملPrevention of isoniazid toxicity by NAT2 genotyping in Senegalese tuberculosis patients
Isoniazid (INH), recommended by WHO (World Health Organization) in the treatment of tuberculosis (TB), is metabolized primarily by the genetically polymorphic N-acetyltransferase 2 (NAT2) enzyme. The human population is divided into three different phenotypic groups according to acetylation rate: slow, intermediate, and fast acetylators. The objective of this study was to explore the relationsh...
متن کاملVisualizing patterns in spatially ambiguous point data
As technologies permitting both the creation and retrieval of data containing spatial information continue to develop, so do the number of visualizations using such data. This spatial information will often comprise a place name that may be “geocoded” into coordinates, and displayed on a map, frequently using a “heatmap-style” visualization to reveal patterns in the data. Across a dataset, howe...
متن کاملUnraveling the Complexities of Life Sciences Data.
The life sciences have entered into the realm of big data and data-enabled science, where data can either empower or overwhelm. These data bring the challenges of the 5 Vs of big data: volume, veracity, velocity, variety, and value. Both independently and through our involvement with DELSA Global (Data-Enabled Life Sciences Alliance, DELSAglobal.org), the Kolker Lab ( kolkerlab.org ) is creatin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2008
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2008.105569